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Public Radio's Environmental News Magazine (follow us on Google News)

April 12, 2002

Air Date: April 12, 2002


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Generation Next, Part 1, Xenotransplantation / Bob Carty

(stream / mp3)

In the first of a five part series we examine the ways in which medical technology is shaping the future of the human species. Producer Bob Carty has the story of one man who is breaking new ground by having brain cells from pigs inserted into his own brain to help him cope with Parkinson’s disease. The procedure is called xenotransplantation. Proponents say it can help many ill people regain their health, and shorten the wait for donor organs. Critics say xenotransplantation may spread diseases that could get out of control. (27:30)

Planetary Traffic Jam

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Host Steve Curwood speaks with David Aguilar of the Harvard-Smithsonian Center for Astrophysics about a unique chance to view the five visible planets in the western sky this spring. (03:00)

Tech Note: Mosquito Needle / Cynthia Graber

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Living on Earth’s Cynthia Graber reports on how engineers are designing a painless needle by learning from mosquitoes. (01:20)

Turkey Trot / Verlyn Klinkenborg

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Spring has arrived, and with it the impulse to get outside, to move and, to mate. Commentator Verlyn Klinkenborg has been watching the turkeys in his backyard begin their dance of desire. (03:20)

Snow Geese

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One way the changing season is marked is by the migration of birds north. Author William Fiennes decided to make a personal quest of the annual snow geese migration, and spent four months following a flock from Texas to northern Canada. He writes of his travels in his first book, "The Snow Geese: A Story of Home," and talks with host Steve Curwood about a journey that ultimately led him to the very place he was trying to escape. (12:00)

This week's EarthEar selection
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Show Credits and Funders

This Week's Music

Show Transcript

HOST: Steve Curwood
GUESTS: David Aguilar, William Fiennes,
UPDATES: Cynthia Graber
COMMENTATORS: Verlyn Klinkenborg


CURWOOD: From National Public Radio, it's Living on Earth. I'm Steve Curwood. This week, we begin a series we're calling "Generation Next." The stories tell how technology is changing the way humans are evolving as a species.

Over the next few months, we'll explore how the science of cloning, genetic manipulation and artificial intelligence are changing what it means to be human. Today, the story of a man who is treating his Parkinson's disease by adding brain cells from another species.

FINN: They bolt you down to the machine. They tie your head down to the machine for two and a half hours. They drill a hole in your scull. And you're awake while this goes on. And they implant the pig cells with a six-inch needle. They implanted 12 million pig cells into my brain, not knowing what the outcome was going to be. They gave me a handshake and a band-aid, and sent me home.

CURWOOD: Xenotransplantation, the first installment of "Generation Next" on Living on Earth, coming up right after this.


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Generation Next, Part 1, Xenotransplantation

CURWOOD: Welcome to Living on Earth. I'm Steve Curwood. It seems hardly a week goes by without some announcement of yet another breakthrough in medical technology. These discoveries, we're told, will revolutionize our lives and give humans the power to direct our own evolution. These technologies include stem cell research, genetic testing, gene therapy, cloning, and xenotransplantation.

In the not-too-distant future, they will make it possible to design our children, clone ourselves, genetically manipulate our intellectual and physical performance, and meld our minds with the artificial intelligence of computers. These technologies will not only revolutionize medicine, they will also change who we are as human beings.

This week, we begin a special series examining how medical science is changing the way we're evolving. The series is called "Generation Next: Remaking the Human Race." It begins with a story about a remarkable procedure called xenotransplantation. It's a term that comes from the Greek word xeno, meaning foreign. And that's what it's all about, putting animal parts into humans.

Xenotransplantation could save thousands of lives and put an end to the terrible tragedy of patients dying while waiting for a human organ transplant. But, there's also a real fear it could set off a terrible pandemic on the scale of AIDS. Here's producer Bob Carty with a documentary he calls "Who is the Real Guinea Pig?"


FINN: This is one of my prized collector's items.


FINN: It's a Zenith AM Transistor Radio, about 1962. It's an old-timer. I had to put new transistors in the chasse, and a new speaker, and a new battery holder.


CARTY: Fixing radios was Jim Finn's passion and his profession. Jim fell in love with radios when he was a boy. And the back room of his home in Newport, Rhode Island is crammed with tubes and transistors, and dozens of radios in various states of disrepair, and repair.

FINN: I was an electronics repair technician--TVs, and stereos, and that sort of thing. I've collected radios all my life and got to the point that I couldn't work on them anymore because my hands just wouldn't cooperate. They were stiff, and they wouldn't move properly. I came down with Parkinson's Disease when I was 32 years old, back in 1980.

CARTY: Jim Finn shares Parkinson's with Mohammed Ali, the Pope, Billy Graham, Yasser Arafat, Michael J. Fox, and half a million Americans. It's a progressively debilitating disease. For some reason, the brain cells of Parkinson's victims stop producing dopamine, a chemical that helps control their muscles. They begin to tremble, shake and jerk. Eventually, they can no longer move voluntarily. Sufferers call it "a living death."

Jim and his partner, Ray, have been living together for 17 years. And over that time, they've watched as Parkinson's gradually began to take over Jim's life.

FINN: The disease progressed and just continued to get worse. I couldn't walk most of the time. I would sleep 18 hours a day because of the sheer exhaustion of this disease. I would shake uncontrollably.

RAY: We used to wheel him around in a wheelchair to get to the supermarket, or to go out for dinner. I used to have one hour a day that he could walk. The rest of the time, he would either be overly medicated, or he just had to crawl.

FINN: By 1996, my Parkinson's had progressed to, what they call, end stage, where they could do nothing more for me. No pills would work. There were no other procedures available to me. And that's when they did a video on me.


FINN: This is a stand-up test to see if you can stand, which I could not do at that time.

CARTY: You almost fell over.

FINN: Yes.

CARTY: In the video, Jim Finn is 48 years old. He looks like he's 90. He twitches, speaks with a slur. He can't move one foot in front of another. He can't get up out of a chair. And then, realizing that, he stares straight at the camera with an expression of confused panic and fear.

RAY: We had been back and forth to Boston University Hospital, and tried multiple, multiple different type of medications. And nothing was working. Nothing was working. He was getting quite depressed.

FINN: I was nearing the point of no return. I thought I was going to die. In fact, I knew I was going to die. I was going to kill myself. It was that horrible.

RAY: And, I could see how somebody would make up their mind that it's not worth going on to live in this manner. So, there was nothing to lose.

CARTY: At that point, at the point when Jim felt he had nothing to lose, in the summer of 1996, a Boston doctor approaches him with a proposition. Would he participate in a high-risk medical experiment? It involves injecting 12 million embryonic cells into Jim's brain. Though, that's not what makes the procedure revolutionary. It's that the cells would come from a pig.

This is xenotransplantation, or xeno. It's been on the margins of medical science for almost a century. But it broke into public consciousness in 1984, with a shocking announcement.

MALE NEWS REPORTER: Tonight, last chance for life. A baby girl is given the heart of a baboon.

CARTY: She was known in the media only as "Baby Fae," a tiny, 14 day-old baby girl born with a fatal heart problem.

MALE NEWS REPORTER: They took out her heart, which would have failed within days, and replaced it with the heart of an infant baboon. It's being called a "major breakthrough" for medical science. And doctors say the baby girl is doing remarkably well after the operation.

CARTY: There had been other xenotransplants before. Chimpanzee and baboon kidneys and hearts had been used in the '60s and '70s. But all the recipients died, their immune systems rejecting the transplanted organs.

In 1984, however, there were new anti-rejection drugs. And doctors were eager to be the first to make the breakthrough. For three weeks, the public was transfixed with gripping headlines of a medical miracle in progress. Maybe, just maybe, xenotransplantation could work. And then the life began to ebb from the tiny Baby Fae.

MALE NEWS REPORTER: Doctors tried cardiac massage before they finally pronounced Baby Fae dead. She survived 21 days. That's the longest any person has survived with a transplanted heart from an animal.

FANO: From reports that I've read there was no effort made to find a human heart for Baby Fae. It showed that people who are trying to try new technologies will do it at the expense of a human life.

CARTY: Alix Fano, is the Director of the Campaign for Responsible Transplantation, a coalition of physicians, scientists, and public interest groups opposed to xenotransplantation.

FANO: What the Baby Fae incident, I think, showed is that these procedures were a failure, and that they were dangerous. Since 1905, about 82 whole organ xenotransplants have been performed, and they have all failed. The patients have all died, mostly within minutes or hours after the xenotransplant. The history, certainly, is very disappointing.

CARTY: Jim Finn knew about this disappointing historical record. But since Baby Fae, research had intensified. Some of it turned towards the use of animal cells, in addition to whole organs. And, more and more, the research turned away from primates.

Animal rights groups had become incensed that reports of experiments with chimpanzees and baboons, intelligent primates, who are our closest relatives. And so, xenotransplantation scientists turned to an animal which, while as intelligent as a dog, it is said, is one we eat: the pig.


GREENSTEIN: You're seeing our miniature swine facility where we're breeding the pigs that we would eventually like to use for human transplantation.

CARTY: These are the kind of pigs they would use for Jim Finn's xenotransplant. Julia Greenstein is the president of Inmerge Biotherapeutics, a company located in a renovated warehouse in the old dockyards of Boston. She shows off her pigs on a video because their exact location is confidential, a precaution against protests or actions by animal rights groups. Julia Greenstein's company specializes in producing pigs that are bred, cloned or genetically altered to make body parts for humans.

GREENSTEIN: We have a certain strain of pig which is called a miniature swine. And we're using that pig because we think the organ size match is better than an outbred pig, which grows to be about a thousands pounds at full adult weight, which is clearly much bigger than most human recipients. It's actually surprising that the physiology is very, very close to man. So, heart rate, blood pressure, respiration rate are all very similar. So, the organs are very similar in function.

CARTY: Xeno research is driven by the huge gap between the number of human organs being donated, and the number of patients desperately waiting for a new heart, or liver, or kidney. Human organs have to come from healthy donors, usually the victims of traffic accidents who are declared brain dead, but whose organs are still alive and can be harvested for transplantation. Seat belts in safer cars mean fewer fatalities, and fewer organ donations.

GREENSTEIN: In the United States alone, there are 75,000 people on various organ waiting lists. And, 15 of those people will die every day because of the unavailability of human donor organs. We believe that, given that need that there is in the population today, there will not ever be enough organ donors to treat everyone who could benefit from an organ. And the overwhelming clinical need means that there is a big potential marketplace, $6 billion a year, to use animals as organ donors. So, there's a big potential win for both society and for a commercial venture in this area.

CARTY: But critics question whether xenotransplants really are needed. Alix Fano of The Coalition for Responsible Transplantation argues that the demand for organ transplants, like lungs, and hearts and livers could be reduced by healthier diets and better living, and that there are other ways to increase the effectiveness of human to human transplants.

FANO: About 50% of transplanted human organs are rejected and fail within five years. So, before we embark on a dangerous and more complex cross-species transplantation, we should try to perfect existing human-to-human transplant techniques. The other would be to increase human organ donation by all means possible. We don't believe that we need xenotransplantation. In fact, it's a perilous road to go down.

CARTY: It's a perilous road to go down, in part, because when animal organs are put in humans, the body's defense systems often attack and kill the transplant and the patient. Now, this is not a problem if the transplant involves no blood vessels for the immune system to attack. And that's why pig insulin, and pig heart valves work, and why rejection is less of a concern in putting pig brain cells inside Jim Finn.

In the future, doctors might get around the rejection problem by using compatible human organs produced from stem cells. But that's years away. It doesn't help people needing transplants right now, people that Dr. Hugh Auchincloss see regularly, as a transplant surgeon at Harvard University.

Auchincloss contends that the rejection problem can be overcome by the use of new drugs designed to suppress the human immune system, or by attempts to "humanize" pigs, genetically engineering pigs by putting human genes into them or by taking uniquely pig genes out. Of course, engineering pigs for human transplants raises the issue of animal rights, and our rights to change the very nature of a fellow species. Hugh Auchincloss has thought a lot about the issue.

AUCHINCLOSS: I think one has to treat animals with respect, and go to great lengths to avoid pain and suffering. But I think, obviously, we make clothes, and eat animal products. And so, using their organs is, to me, no different. I, myself, am in a group of people that feels comfortable with the notion of using animals for human welfare.

FANO: Ultimately, you're killing them for their organs. Or, for example, you're deriving sterile embryos by caesarian, by a mother pig, and then killing her, and taking her embryos so you can inject them into somebody's brain. Is this necessary use of animals? I, personally, don't think so.

FINN: The use of animals for testing cosmetics and household cleaners, I think, is disgusting and deplorable. But when an animal can help mankind, I think if it's done properly and humanely, I say go for it. The people who are against these kind of procedures have never had a relative or loved one who had a serious or horrible disease. Six or eight people a day are dying of heart failure, kidney failure, liver failure. This offers help to those people. And I was one of those people.

CARTY: One of only 12 people, in fact, selected to take part in the first Parkinson's trials with pig cells. The idea is to replace some of Jim Finn's brain cells, degrading and dying, with cells from pig embryos. The hope is that, once in his brain, the pig cells will produce dopamine, and reduce the symptoms of Parkinson's. Jim has no qualms that the cells come from pigs.

FINN: Didn't make any difference to me at all whether they're pig cells, or horse cells, or cow cells, or no matter what they were. I felt I had nothing to lose. So, I went for it.

CARTY: What did you think about this technology?

FINN: I put my faith in medical science. The pig cells are specially selected from specially bred pigs that are pure, as far as they know. The pig cells are obtained from pig fetuses. I believe it takes nine fetuses for one operation.

MAN: And then we collect the fetuses from those pigs.


CARTY: Jim Finn's pig cells are harvested by a company called Diacrin, which has bred pigs just for this purpose. In a British documentary by Carleton Television, a Diacrin scientist explains the procedure.

MAN: They're extracted under very clean conditions. And, during that procedure, we dissect out specific areas of the fetal brain.

CARTY: In the video, the pig fetuses are each about the size of a small carrot. They are poured into a laboratory tray. Then a scalpel cuts off the head, opens the skull, and extracts the cells from a particular part of the brain. That's how the cells were prepared for Jim Finn.

FINN: Everything was carefully explained to me, the possible pitfalls. The risks were relatively unknown. There was a two percent chance of a brain hemorrhage, which would not be a nice thing to go through. There was a possibility the cells would multiply beyond what they expected. And that could lead to brain damage. There was a possibility that it would have no effect at all, or any kind of side effects that were unknown.


CARTY: On September 24, 1996, Jim Finn checks into a Boston area hospital at 6:30 in the morning. They put him in a gown, take yet another CAT scan, and an MRI, and attach a metal frame to his head. Jim is ready to take his leap of faith in medical science.

FINN: When it come to the operation, you go to the hospital. They bolt you down to the machine. They tie your head down to the machine for two and a half hours. Your head is literally bolted to the machine. They drill a hole in your skull, in my head right there, where they put the drill. And you're awake while this goes on. And they implant the pig cells with a six- inch needle. They implanted 12 million pig cells into my brain, not knowing what the outcome was going to be.


FINN: The amazing thing is, after the operation, they send you home the next day. They gave me a handshake and a band-aid, and sent me home.

CARTY: Jim Finn goes home to wait. And waiting is a big part of xeno research. The pig cells they put in his brain are living things. And they grow and replicate, and can be unpredictable. And they'll be in Jim's brain forever. They can't be taken out.

Currently, xeno recipients, like Jim Finn, have to monitored for their entire lives. That's because pig cells and organs can carry diseases which could become a problem, not just for the transplant recipient, but for all of humanity. And that's what most worries Alix Fano of the Campaign for Responsible for Transplantation.

FANO: The issue is that pigs are not safe source animals for xenotransplantation. There has been a history of pig virus transfer to humans, beginning with the swine flu epidemic of 1918, which killed about 20 to 40 million people worldwide. Recently, in 1998, the Malaysian Nipa-virus was transferred from fruit bats to pigs, and then from pigs to people who worked in slaughterhouses. And, it killed over 111. Xenotransplantation is probably the best way that you could invent to create a new epidemic, in the sense that you're transplanting live pig tissues, or organs, into immunosuppressed patients. And, it only takes one transplant to start an epidemic.

CARTY: This is the big debate in xenotransplantation. Pigs do get viruses. And over millions of years of evolution, some of those viruses have become embedded in the pig's genetic code. They are called retroviruses. And over the eons, pigs have learned to live with them. The viruses don't make the pigs sick.

But viruses are dangers packets of information. And one of the things they do best is adapt and mutate. The concern is that inside a recipient's body, pig cells or a pig organ might share the pig retroviruses with our own human viruses, and create some entirely new disease.

Could that happen? "Yes," says Hugh Auchincloss, the Harvard transplant surgeon. But Auchincloss does not think the risk is great.

AUCHINCLOSS: It actually turns out that as many as three or four hundred people have had tissue from animals transplanted into them. But a large number of those people have been carefully examined to see if there's any evidence of the spread of these endogenous retro viral sequences. And there's none, none at this point.

Now, there is a very tiny, conceivable risk that there might be viruses that, so far, have not been identified, or could be created by the process of xenotransplantation, that might also be a risk for society at large.

CARTY: Tell me about that, in terms of the larger risks.

AUCHINCLOSS: It's extremely hard to assess the nature of a risk of an event that has never occurred. So you can talk yourself into a worst case scenario. Or you can be realistic and say that a worst case scenario is, in fact, really a very unlikely event.

CARTY: But others are not so quick to discount the risks of xenotransplantation. Robin Weiss is a virologist at University College in London, England. He's an expert on HIV/AIDS, an epidemic that came from a single jump of a virus from a chimpanzee to a human. Weiss decided to test whether pig viruses could affect humans. He put pig cells and human cells together in a test tube, and then looked to see if the one infected the other. He was very disturbed by his findings.

WEISS: We found, in fact, there were three infectious strains of pig retrovirus. And two of those three strains would infect human cells. This immediately set alarm bells ringing. One of the biggest safety concerns is that animal infections, particularly animal viruses, might set off an epidemic. And most transplant surgeons, and so on, say, "Oh, that's so far-fetched. Why bother about it?"

The problem is that far-fetched things do happen with animal infection spreading to humans. The worst case scenario is that we'd set off something like a new AIDS epidemic; that a pig virus would become established in the human population, be a killer virus, and would start to spread.

CARTY: What do you say to a patient who has something like Parkinson's when you understand their willingness to do almost anything versus your public health concerns?

WEISS: I think from the point of view of the ill person who may become a recipient of animal cells or organs, the risk benefits balance is fairly easy to look at. In a large proportion of cases, I think they'll say, "Well, I'm so damned ill, I'll take the chance." But there's also the public health point of view. I don't think any patient, however ill they were, would like to think that they were the cause of a new world-wide epidemic of the similar nature to AIDS.

CARTY: Robin Weiss's research has put a brake on xeno experimentation. In the U.S., testing with cells is continuing, but at a very slow pace. Testing with whole organs is now on hold, until the risks of an epidemic can be eliminated or better assessed.

But how do we make such an assessment? Fritz Bach has one idea. Bach is a professor at Harvard Medical School and a pioneer in xeno research. He wants it to work. But he says that since the public is exposed to the risks of xenotransplants, the public has to be asked to give its informed consent.

BACH: We cannot put the public at potential risk without going to the public, explaining to them, in a balanced way, what the risks are, and what the benefits are, and then getting their reaction. That cannot be decided ethically by those people who want to do xenotransplantation, like me.


CARTY: Jim Finn is very aware of these issues when he checks into the Boston hospital for his xenotransplant. Before he's bolted down to the operating table, he has to sign a detailed consent form, a list of rigid rules that will govern how he lives.

FINN: They made me sign this 27 page consent form. You have to agree to be monitored for the rest of your life. Barrier sex only, with a condom. You have registered with a government agency as a xenotransplantation recipient. You have to have blood work done when they want, to be sure you're not carrying a virus.


CARTY: When Jim and his partner, Ray, get back from the hospital, Jim starts to write a diary. Looking down on him from the desk is Priscilla, a puffy, pink toy pig. The diary is something to share by internet with other Parkinson's sufferers, a record of how Jim's body is reacting to the 12 million pig cells living in his brain.

FINN: Thirty days after, I felt results. My motions were smoother and better, more accurate. I could walk better. I could talk better. I could use my hands. Everything improved. Very subtly, but there was a definite improvement.

RAY: I'd say about three or four weeks, maybe six weeks after the surgery, we were out for dinner. And, he was cutting up a dinner roll and he was buttering it, which was something that I always ended up doing for him. That was my job. And, he was just talking away, nonchalantly, and doing it, not even realizing. And I had to just point out to him, "Do you know what you just did?" So, we did finally get rid of that wheelchair. We put it up in the garage, and that's where it's been ever since. So, he's doing great.

FINN: At the 60 day point, they measured an improvement, and they were amazed.

CARTY: And you can see the difference in Jim's before and after videos. After the operation, you see him walking smoothly, getting out of a chair without a problem. In the tests before the operation, his reading is slow, and lacking modulation.

FINN: [1st Reading] -- mind in one area, and distracting it from the hurt in the other. Dr. William Evans Trent, 1990. [2nd Reading] It's like pinching the mind in one area, and distracting it from the hurt in the other. Dr. William Evans Trent, 1990.

CARTY: Afterwards, he reads with greater energy and confidence, even joking with his nurse.

FINN: Seven, eight, nine, ten. Did I do good?

NURSE: Very good.

FINN: I was tested every 90 days for the first, I think, three years. And they showed improvement or holding my own in every test. My handwriting is still lousy. But it was lousy before I had PD anyway.

CARTY: How do you feel with cells of a pig inside you? Is there any qualms about that?

FINN: No. People were very curious about this procedure. They wanted to know if I felt differently after I had pig cells implanted in me. I said, "No, I don't feel any different. I feel better." I've heard every goddamn pig joke you can imagine. One day, when I was in my doctor's office, he asked me to turn around. I said, "Why?" He said, "I want to see if you have a tail or not." I told him to go to hell.

CARTY: There is no doubt in Jim Finn's mind that the pig cells are the cause of the improvements in his health. But scientists are not so sure. Other trials have been disappointing, or inconclusive, with those receiving pig cells doing no better than a control group given a placebo.

But Jim Finn feels xeno was the only option for him. Five years after his operation, the doctors have not found any signs of pig viruses in his blood. Jim, in fact, has become somewhat of a poster boy for pig transplants. He's on a Washington committee studying the technology. A few months ago, he was even on Oprah, talking about medical miracles. Jim knows he's not cured. And he understands that xenotransplantation may or may not have a future. But now, at least, he does.

FINN: It changed my life. It gave me my life back. I take it a day at a time. You don't know if this experiment could suddenly fail or go awry. They have no way of knowing these things. They gave it their best shot, and so did I. Now I can work on the radios. It's a little bit slow, and a little bit awkward, but I can do it.

FINN: This is one of the pieces I've recently fixed up. I was in Boston last week for my fifth year checkup. And, I celebrate it as a birthday. Because I feel as if I've been reborn.


CARTY: For Living on Earth, I'm Bob Carty.

FINN: I'm not much of a dancer.

[MUSIC: Nick Cave, "Into My Arms," THE BOATMAN'S CALL (Mute - 1997)]

CURWOOD: Next in our series, the controversy over human cloning. Some advocates say it will give us better control over human reproduction. But critics say it's unethical, and could change human values.

WOMAN: Many of the technologies that we're talking about do turn having a child into something akin to buying a car, picking the extras, and so forth. What is society going to look like if we adapt one set of technologies, one set of laws versus another? And I think it's time to look a little bit ahead, and ask, really, "Do we want to go there?"

CURWOOD: The human cloning debate is the topic when our series, "Generation Next: Remaking the Human Race," continues on Living on Earth.


CURWOOD: Your comments on our program are always welcome. Call our listener line anytime at (800) 218-9988. That's (800) 218-9988. Or write to 8 Story Street, Cambridge, Massachusetts, 02138. Our email address is letters@loe.org. Once again, letters@loe.org. And visit our webpage at www.loe.org. That's www.loe.org. CDs, tapes and transcripts are $15.00.


Related link:
Generation Next: Re-making the Human Race, a five part series

Jim Finn's Diary

The Campaign for Responsible Transplantation

Islet Foundation (diabetics in favor of xenotransplantation)">

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Planetary Traffic Jam

CURWOOD: You're listening to NPR's Living on Earth. If you spend an evening outside over the next few weeks, you'll get a chance to see a unique grouping of the five visible planets. David Aguilar is with the Harvard-Smithsonian Center for Astrophysics, and he joins us now. Hi there.


CURWOOD: So, what are these planets we'll get to see?

AGUILAR: First of all, you're going to get to see Mercury, Venus, Mars, Jupiter and Saturn.

CURWOOD: Now, if we want to check out this planetary traffic jam, where should we look? And, what exactly are we going to see?

AGUILAR: Just look west at sunset, and its going to be displayed right in front of you. It's going to be a gigantic traffic jam of the ancient gods across the sky, in a straight line originating from the western horizon where the sun set, and moves almost up to the center of the sky.

CURWOOD: This straight line is known as the "ecliptic?"

AGUILAR: That's correct. It's the ecliptic. It's also what the Greeks and Romans considered the "highway of the gods," because these planets were gods to them. It's this line, this highway across the sky, that the 12 constellations in the sign of the zodiac are found.

CURWOOD: Now for someone who really wants to take a good look at this, the best time of day to go out and look is?

AGUILAR: At sunset. Go out at sunset; watch the sun go down, because that's going to be your starting point. As it gets darker, as the twilight begins to fade, you'll begin to pickup first Jupiter, because it's the brightest, then Venus, then Saturn. And then, finally, Mercury and Mars are going to pop into view.

CURWOOD: What is the very best night to take a look at this?

AGUILAR: The two nights that I am absolutely looking forward to are, first of all, May 5th. That's when the planets Mars, Saturn and Venus are going to come together, and form a beautiful equilateral triangle in the sky. Then, on May 10th, the planets Mars and Venus are going to occult each other, or come so close together. Actually, they don't occult. But they come so close together that, to the naked eye, they will appear as one star-like object in the sky.

CURWOOD: Now, when was the last time we saw that triangle you talked about for May 5th?

AGUILAR: Well, the last time-- the most famous time that we found, when we set our star charts back, was 2 B.C.

CURWOOD: What did this look like back in the year 2 B.C.?

AGUILAR: Well remember, first of all, there weren't any lights. So the sky would have been very dark and, more than likely, over the desert regions, quite clear. So, it would have been stunning. Many people believe that it may have been a formation of planets that the Magi saw, and started them on their journey from what we call Iraq today to the Holy Land in Jerusalem.

CURWOOD: And if the Magi had been in Iraq, which direction would this have appeared to have been?

AGUILAR: They would have been looking west. And, directly west from them is the country we call Israel today, but Jerusalem. Now I must say, there are some historians, and one of them right here at Harvard-Smithsonian, believes that the Magi wouldn't have paid any attention to these planets. And in fact, they were looking for different signs in the sky. So, there's a lot of controversy over what this might have meant to early people.

CURWOOD: David Aguilar is with the Harvard-Smithsonian Center for Astrophysics. Thanks for taking this time with us today.

[MUSIC: Trisomic 21, "Hazy Ridge," A MILLION LIGHTS (Play It Again Sam - 1987)]

AGUILAR: You're welcome.


Related link:
Harvard-Smithsonian website on the planetary line-up">

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Tech Note: Mosquito Needle

CURWOOD: Coming up, why turkeys are hot to trot right now. First, this environmental Technology Note from Cynthia Graber.


GRABER: When a mosquito bites us its stinger, or proboscis, goes in and out of our skin painlessly. That painful pinch we feel is the anti-coagulant saliva that irritates our skin, and then makes the spot itchy and scratchy. The reason the sting itself is painless is that a mosquito's stinger isn't smooth. Its edges are actually serrated, so fewer points meet sensitive nerve endings. Unlike a mosquito stinger, medical needles are made of smooth metal, and come in contact with nerve endings at every possible point during insertion into our skin.

So engineers in Japan decided to make a painless needle by mimicking the mosquito's design. They cut microscopic jagged edges into silicon dioxide, and then bonded the pieces together. The end result: a needle that's only one millimeter long, and one-tenth of a millimeter in diameter. In preliminary tests, it pierced through a piece of silicone rubber, used to imitate skin.

Right now, this painless needle is too brittle, and could break off after piercing human skin. So engineers are still refining their design for human tests. That's this week's Technology Note. I'm Cynthia Graber.


CURWOOD: And you're listening to Living on Earth.

[MUSIC: Medeski, Martin & Wood, "Smoke," UNINVISIBLE (Blue Note - 2002)]

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Turkey Trot

CURWOOD: It's Living on Earth. I'm Steve Curwood. And coming up, author William Fiennes confronts the urge to wander, and the urge to get back home. But first, Spring Fever may be a human condition, but we're not the only creatures of passion as the days get longer and warmer. Verlyn Klinkenborg has been observing another species perform its vernal ritual.

KLINKENBORG: A couple of months ago, I began getting up at four in the morning. I had been reading a lot of William Cobbett, a reformer who lived and wrote in England in the early 19th century. Cobbett believed an hour in the morning was worth two in the afternoon. And his idea of morning began at four.

I don't usually imitate the lives of the writers I read. Who would want to? But for Cobbett, in this case, I was willing to make an exception. Once when he was living in America, he met a driver who was surprised at how much Cobbett got done during the day. A born explainer, Cobbett said, "I rise early, go to be early, eat sparingly, never drink anything stronger than small beer, shave once a day, and wash my hands and face clean three times a day, at the very least." The driver said, "That was too much to think of doing."

The dogs are thrilled to get up at four because it means they run around outside for a few minutes, have their breakfast, and be back in bed by 4:15. For a few weeks, in mid-winter, I had the early morning darkness all to myself. The February sun seemed as lazy as that American driver. But week by week, the darkness has eroded, crumbling sooner and sooner every morning.

And when dawn comes, the turkeys come with it. They slip out of the woods in the middle pasture, a flock of twenty-some birds, almost every morning. Some days, they scratch their way slowly downhill, stopping here and there to wipe their feet the way the chickens do. Other days, the flock pours down the hillside, making their way to the spot where we spread cracked corn for them.

In the early morning dusk, they look like low, hunched shadows. But as the light grows stronger, it catches the copper, and bronze and brass of their feathering. They move more sinuously than I had ever imagined, their heads no larger than afterthoughts. While winter lingered, it was hard to say just who was who in the flock. Spring settled that.

I looked out in the pasture last Sunday morning and saw a tom turkey bestriding a hen, fully inflated by a sense of self and genetic duty. He let himself down until he looked no different from the rest of his harem, who are slender birds. Then he blew himself up again. His body swelled and turned black before my eyes. He became globular. He turned blue and white in the face, and red in the waddles. His wings fell to his side, and his primary feathers reached out to the ground. His tail fanned and pivoted side to side as he shuffled forward like a dancer in the Mikado. This was spring in all its glory, all its urgency.

Then he trailed his way uphill toward the other male, and they dueled with each other as though they were dueling with a mirror. The hens kept after the cracked corn, and never once looked up.

[MUSIC: Bill Monroe & Doc Watson, "Turkey in the Straw (banjo)"]

CURWOOD: Verlyn Klinkenborg writes about the rural life for The New York Times.


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Snow Geese

CURWOOD: From time to time, most of us feel the need to escape, to stray from the comfort of home, and venture into the unknown. When William Fiennes caught the wandering bug, he decided to take wing, literally. For four months, he followed snow geese over a three thousand- mile path as they made their way from Texas to Canada on their spring migration.

He's written about the places he visited, and the people he met along the way, in his first book, "The Snow Geese: A Story of Home." The journey, he says, was a way to escape home, and the effects of a serious illness.

FIENNES: It really came out of a fairly difficult period of my life. I fell ill when I was 25, and really found myself pretty struck down. And I went to convalesce at my childhood home, where my mother and father still lived. And it was while I was there that I found this book by Paul Gallico called, "The Snow Goose," which was a story I remembered from childhood.

This very charming, rather touching story about a snow goose that gets blown across the Atlantic by a storm as it's migrating south from Canada. And it's shot down by a hunter over a coastal marsh in England. And it's cared for and looked after by a man called Rhayader, who's living as a hunchback and a hermit in this abandoned lighthouse.

And I suppose in this story, with all these images of birds migrating to and from their native place, and getting restless at a certain time of year, and finding their way back to their winter grounds, or breeding grounds, it really moved me. And, it was a kind of a quest that I would find snow geese in Texas, and when they started heading north with the spring, I would go with them. And I'd go up to Canada if I had to, and up to their breeding grounds.

CURWOOD: Let's talk a bit about the geese here. How do snow geese find their way home?

FIENNES: In waterfowl, it's suspected that, to some degree, experienced birds guide younger birds. But, at the same time, it's known that there are whole series of compasses, inherited compasses, that birds use to find their way from one place to another.

And these include a sun compass. And because they have an internal clock, they can compensate for the sun's movement during the day. They have a star compass so they can migrate by the positions of the constellations, and particularly the way they relate to the axis of the earth's rotation. Birds also use a magnetic compass, responsive to the field lines of the earth's magnetic field. So, there's a sort of whole set of navigational mechanisms with a built-in redundancy so that some will become useful when others aren't applicable.

CURWOOD: William, there's a point in your journey where you're standing on the edge of Sand Lake. It's in South Dakota. And you're watching the snow geese fly in. Could you read a little from this, please?

FIENNES: Sure. The ice was covered with snow geese, a thick sewn crop of white necks right across the lake. Suddenly, the flock took wing, an audience breaking into applause. It was as if the ice itself had exploded. The flock seethed, rolling back and forth on itself, its shadow roiling like a turbulence on the ice below. The applause deepened to the sound of trains thundering through tunnels. Scarves of glitter fell through the flock when drifts of birds turned their backs and white wings to the sun. And sometimes, the entire sky was lit with shimmer, as if a silver sequined dress were rippling beneath a mirror ball. The sounds of goose calls and beating wings pounding the ice below.

I witnessed collisions, caroms and buffetings of blue face and white face snows, one bird's heft glancing off another's; the "O" of my binoculars, a frenzy of black tipped wings. Then, as before, the first bird settled on the ice, followed by others, each goose taking its place, the gaggle reforming bird by bird, the roar diminishing, until the whole flock was spread before us on Sand Lake.

CURWOOD: It's just amazing. How could you breathe and see something like that?

FIENNES: Well, in fact, there's a description a few pages before when I do say, "For a moment, I had forgotten to breathe." Because it was so extraordinary. And these were particularly large flocks they were getting, 200- 250,000. And this was one thing I learned on the way, that there's no extinction danger for snow geese. Their numbers have been burgeoning. And this is all to do with the agricultural development of the Great Plains. They've got a constant supply of waste grain and rice all on their way north.

They've been incredibly successful. And almost too successful, in that now they're destroying a lot of their habitat along the edge of Hudson Bay. And that's having a big knock-on affect on other species that rely on those habitats. But it was extraordinary to me.

CURWOOD: At one point in this book, you write that you were at the mercy of snow geese throughout their migration. Can you explain what you mean by this?

FIENNES: Well, I suppose when I started, I'd imagined that it would be quite a smooth flight from Texas to Foxe Landing in Baffin Island. But in fact, it's a sort of edgy, stage-by-stage thing. I hadn't realized the extent to which the geese would be sensitive to the weather. And they really fly on the leading edge of spring, and try and sort of push up as far north as they can go.

But if it's wintry and cold, and the lakes are still frozen ahead of them, they'll hang back. So sometimes I'd actually see them flying southwards, and think, "No. That's the wrong way." So this meant that sometimes I'd just have to sit and wait. And, often this happened for sort of two weeks, three weeks. So I did feel sort of shackled to them. And, I felt at the beck and call of geese, and often wondered if that was a particularly healthy thing to be.

CURWOOD: I have to wonder if there was a point that you felt that you just should pack it all in, that maybe this thing was for the birds.

FIENNES: Yes. There were some really down moments. I mean, I was traveling alone for almost four months, and traveling increasingly in quite, sort of remote and lonely places. I had moments thinking that all quests were, in some way, futile. But I was incredibly lucky in that, whenever I had one of those moments, something would happen. Some person would be kind. Or, some amazing little tributary adventure would take place. And somehow, my spirits would be lifted.

CURWOOD: Tell me about some of these people you met along the way, some of the folks who took you in, or helped you out, and their relationship to the geese.

FIENNES: Well, there was a wonderful biologist in South Dakota who'd been at this wildlife refuge for 20 or 30 years. And I used to drive around in his pickup. And he'd test me on the names of the ducks. And there were some people who weren't really interested in birds, particularly. I remember sitting on a Greyhound bus, next to a former nun. And she talked my ear off, and told me wonderful stories about life in the convent. And once she broke a statue of St. Joseph, and this was Mother Superior's favorite statute. And, if they broke anything, they were forced to sleep with it. And so, this nun, Jean, was forced to sleep with her statue of St. Joseph. And a lot of people told her that she was lucky just to have a man in her bed.


And then there was a wonderful guy who'd run away from home, and had lived as a hobo, jumping the freight trains from one side of Canada to the other. And he really talked my ear off. He said that, when he was at school during the war, when they'd been doing the vaccination programs, they jabbed everyone with a vaccination needle. But when they got to him, they had run out of needles. So they jabbed him with a gramophone needle instead. And since then, he never stopped talking.


And there was just this great outpouring of life in story. And, I've tried to introduce certain characters as vividly as I could. Because their stories amplify the theme of the book, and this sense of longing for home that runs through it.

CURWOOD: In a sense, you talk a lot about homesickness being a disease. Tell me about those ancient theories, and what was the basis for them?

FIENNES: Well that, again, I found just so interesting. And, the more I looked into it, the more interesting it became, just as a sort of medical phenomenon. And I had no idea that in the 16th and 17th centuries, people were actually dying of homesickness. It was a medically recognized condition.

And at the beginning, it was thought that homesickness particularly afflicted the Swiss. It was known as the "Swiss disease." And the reason for this was that it was thought that the Swiss, because they live in the mountains, that they're subject to less atmospheric pressure weighing down on them up in the mountains. And that when they leave Switzerland, and they go to the low countries, the pressure would be much more intense, and then they'd start showing these symptoms. And the cure would be to get them up as high as you could as quickly as possible. They were told to go and climb a hill, or climb a tower or something.

And there are amazing stories. A lot of them coming from the military doctors in the 17th and 18th centuries about how really nostalgia, or homesickness, was about the kind of biggest problem facing military doctors. And I suppose one of the things I wanted to get into the book is the idea of a sort of healthy nostalgia as well as an unhealthy nostalgia.

CURWOOD: I want to take you back to the moment when, towards the end of this trip, you wind up in this Inuit community in northern Canada, and you go out hunting. Can you tell us the story of this hunting trip?

FIENNES: Well I got to Cape Dorset on Baffin Island. And I went to see the Hunters and Trappers Association. And, each of the Inuit communities will have one of these HTA's. I wondered if there was some way somebody who might be prepared to take me out of the community into the tundra where the geese would be coming down and landing as they really came into their breeding range.

And eventually-- well, the next day-- they came back to me and said that a lady, Paula, and her son, Natsiq, were going hunting, and they'd be happy for me to go with them. So I set out with these two, with this strange pair, for about three days. And then, when we started shooting geese, I realized that that was what we were going to eat, that was what we were going to live on for the three days. And, Paula plucked the goose, and rolled out its innards onto the snow, and boiled it, and seasoned it with a sachet of Lipton's Onion Soup. That was the essential ingredient.

And, I had this strange kind of communion of feeling a sense of sort of total immersion with the object of my quest. And, although that was not what I'd expected, it felt sort of right somehow, that that's how it had all ended. And then knew it was time for me to go home. And, that had been exerting a kind of constant pull, just as the pull of the excitement, and the freshness of these amazing landscapes and scenes had been exciting me before.

And, I suppose that transition was definitely part of a kind of getting well, and a part of a growing up, that was all wrapped up in the kind of right of passage this migration turned out to be.

[MUSIC: Kate Rusby, "The Wild Goose," SLEEPLESS (Compass - 1999)]

CURWOOD: William Fiennes is author of "The Snow Geese: A Story of Home." William, congratulations on your first book, and thanks for speaking with me today.

FIENNES: Thanks, Steve. Thanks for having me.

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CURWOOD: And for this week, that's Living on Earth. Next week, the Mexican government and an international conservation group put their money and their muscle together to save monarch butterfly habitat in central Mexico. They're paying villagers not to cut down trees.

MAN: We need to protect those forests for the use by the butterfly. But, we're going to compensate you not using the forests so the forest stays. So a whole new paradigm comes into play here. That's the big concept of the project.

CURWOOD: Buying timber and time for the monarchs, next time on Living on Earth.



CURWOOD: We leave you this week with a few sky honkers. At dawn, at a campsite on the edge of a huge field near Holdrege, Nebraska, Lang Elliott and Ted Mack have set up their microphones. A lone Canada goose flies overhead, followed by a pair headed in the opposite direction. Red-winged Blackbirds sound off from a nearby marsh. And in the distance, the distinctive "meows" of Redhead Ducks.

[Lang Elliott & Ted Mack, "Sky Honkers," WINGS OVER THE PRAIRIE (EarthEar - 2002)]

CURWOOD: Living on Earth is produced by the World Media Foundation in cooperation with Harvard University. Our production staff includes Anna Solomon-Greenbaum, Maggie Villiger, Jennifer Chu, Jessica Penney, and Gernot Wagner, along with Peter Shaw, Leah Brown, Susan Shepherd, Carly Ferguson, and Milisa Muñiz.

Special thanks to Ernie Silver. We had help this week from Rachel Girshick and Jessie Fenn. Alison Dean composed our themes. Environmental sound art courtesy of EarthEar.

Our Technical Director is Dennis Foley. Ingrid Lobet heads our Western Bureau. Diane Toomey is our science editor. Eileen Bolinsky is our senior editor. And Chris Ballman is the senior producer of Living on Earth. I'm Steve Curwood, executive producer. Thanks for listening.

WOMAN: Funding for Living on Earth comes from the World Media Foundation Environmental Information Fund. Major contributors include The William and Flora Hewlett Foundation, supporting reporting on Western issues. The Oak Foundation. The National Science Foundation, supporting environmental education. And, The Corporation for Public Broadcasting, supporting the Living on Earth Network, Living on Earth's expanded internet service.

MAN: This is NPR, National Public Radio.


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